Clinical Trials & Research

A second study of the injectable anti-obesity medication, semaglutide, has confirmed the large weight losses reported in a study earlier this month, establishing the reliability and robustness of this new drug. With obesity affecting more than 40 percent of American adults, the findings could have a major impact on weight management in primary care and
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University of Alberta researchers have found that limiting the amount of fat the body releases into the bloodstream from fat cells during heart failure could help improve outcomes for patients. In a recent study published in the American Journal of Physiology, Jason Dyck, professor of pediatrics in the Faculty of Medicine & Dentistry and director
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Widely used medications for benign prostatic hyperplasia (BPH) – also known as enlarged prostate – may be associated with a small, but significant increase in the probability of developing heart failure, suggests a study in The Journal of Urology®, Official Journal of the American Urological Association (AUA). The journal is pub lished in the Lippincott
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Researchers in the United States have conducted a study demonstrating the real-world effectiveness of the recently approved Moderna and Pfizer/BioNtech vaccines at protecting against infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19). The team – from Nference in Cambridge, Massachusetts and the Mayo Clinic in
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The ability to speak is one of the essential characteristics that distinguishes humans from other animals. Many people would probably intuitively equate speech and language. However, cognitive science research on sign languages since the 1960s paints a different picture: Today it is clear, sign languages are fully autonomous languages and have a complex organization on
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With the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Wuhan, China, the coronavirus disease 2019 (COVID-19) pandemic began. In just over a year, the virus has caused over 109 hundred million documented infections and taken more than 2.4 million lives. A new preprint on the bioRxiv* server describes the development of a
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A subtype of asthma in adults may cause higher susceptibility to influenza and could result in dangerous flu mutations. University of Queensland-led animal studies have found that paucigranulocytic asthma (PGA) – a non-allergic form of the condition – allows the flu virus to flourish in greater numbers in sufferers. UQ PhD candidate Ms Katina Hulme
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The etiological agent of the coronavirus disease 2019 (COVID-19) – severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – was first identified in Wuhan, China, in December 2019. Since then, the virus has infected more than 107 million people worldwide and caused over 2.4 million deaths. Due to its high transmissibility, it has been difficult to
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Novel genetic associations could pave the way for early interventions and personalized treatment of an incurable condition. Scientists from the University of Bergen (Norway) and Karolinska Institutet (Sweden) have discovered the genes involved in autoimmune Addison’s disease, a condition where the body’s immune systems destroys the adrenal cortex leading to a life-threatening hormonal deficiency of
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Hydroxychloroquine does not reduce deaths from COVID-19, and probably does not reduce the number of people needing mechanical ventilation, state the authors of a new Cochrane Review. In addition, they note that no new trials of hydroxychloroquine or chloroquine for treating COVID-19 should be started. Authors based in India, South Africa, and the UK (LSTM,
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Using publicly available coronavirus disease 2019 (COVID-19) data from Israel, a study suggests the BioNTech-Pfizer BNT162b2 vaccine is proving highly effective in the real world. Several vaccines have now been approved for COVID-19, and many countries have started intensive vaccination programs. In Israel, vaccination started on December 20, 2020. By the end of January, 33%
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Amid the coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), high-risk populations face the threat of developing severe symptoms. These include older adults and those with comorbidities, such as cardiovascular disease, diabetes, obesity, and hypertension. Now, researchers at the University of Glasgow and the Manchester Metropolitan University in
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Alongside the effects of lifestyle, including physical exercise and diet, on aging, research has increasingly turned its attention to the potential cognitive benefits of musical hobbies. However, such research has mainly concentrated on hobbies involving musical instruments. The cognitive benefits of playing an instrument are already fairly well known: such activity can improve cognitive flexibility,
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Caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, coronavirus disease 2019 (COVID-19) exhibits a wide spectrum of clinical presentations and outcomes – from asymptomatic to severe or even fatal. To date, the virus has spread to more than 192 countries, with over 106 million confirmed cases and more than 2.3 million deaths. The
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New research finds caffeine consumed during pregnancy can change important brain pathways that could lead to behavioral problems later in life. Researchers in the Del Monte Institute for Neuroscience at the University of Rochester Medical Center (URMC) analyzed thousands of brain scans of nine and ten-year-olds, and revealed changes in the brain structure in children
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Professionalization in any field requires long-term experience and training. In the past decades, studies have demonstrated that the professionalization of athletes and artists create differences in the behavior of the brain while carrying out activities related to their area of expertise. To detect the effects of media professionalization in the brain, a research team from
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After reanalyzing data from 500,000 people in Israel who received the Pfizer vaccine, researchers suggest a single dose provides sufficient immunity after about 21 days, thus providing support for the UK’s decision to delay the second dose to 12 weeks. The coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2
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Quarantining potentially infected individuals is a widely used approach for controlling the spread of viruses and other infectious pathogens. Even in the case of the current coronavirus disease 2019 (COVID-19) pandemic, caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a 14-day quarantine has been recommended by the US Centers for Disease Control
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In the year since the coronavirus disease 2019 (COVID-19) pandemic began, there has been a huge investment of research attention into the virus that causes it, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). As such, many experimental studies have taken place to help unravel the structure and biochemistry of the globally dominant variant of
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Throughout the coronavirus disease 2019 (COVID-19) pandemic, many outbreaks have been observed among people in enclosed and close-quarters living environments, such as nursing homes and detention facilities. Caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the disease is easily transmissible, particularly in crowded areas or places where people congregate. To assess the transmission
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Nagoya University researchers and colleagues have revealed that colorectal cancer tissues contain at least two types of fibroblasts (a type of cells found in connective tissue), namely, cancer-promoting fibroblasts and cancer-restraining fibroblasts, and that the balance between them is largely involved in the progression of colorectal cancer. Their findings, recently published in the journal Gastroenterology,
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A new report combining forecasting and expert prediction data, predicts that 125,000 lives could be saved by the end of 2021 if 50% or more of the U.S. population initiated COVID vaccination by March 1, 2021. “Meta and consensus forecast of COVID-19 targets,” developed by Thomas McAndrew, a computational scientist and faculty member at Lehigh
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A recent study, currently available on medRxiv* preprint server, shows that long-term adaptive immunity to endemic coronaviruses is widespread, but low in magnitude, and that it shares phenotypic features of spike-specific antibodies and T cell memory across all tested coronaviruses. Unlike the highly pathogenic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the a causative agent
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Blood is vital to life, and a healthy body replenishes worn-out blood cells with new ones throughout one’s lifetime. If something goes wrong with this process, serious illness will result. Researchers from the National University of Singapore (NUS) have now discovered a mechanism controlling the replenishment of blood cells, which could have relevance for new
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