Clinical Trials & Research

Reviewed by Emily Henderson, B.Sc.May 22 2020 Babies with Hirschsprung’s disease are born with an incomplete or absent gut nervous system. Children’s Hospital Los Angeles investigator Tracy Grikscheit, MD, runs a laboratory that investigates the therapeutic potential of tissue engineering – the induced growth of healthy tissue using stem cells. In a new study, Dr.
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Reviewed by Emily Henderson, B.Sc.May 22 2020 An online treatment proven to prevent anxiety and depression in young people is set to become available to the NHS and other mental health services worldwide. The University of Exeter has developed and tested an effective internet-delivered treatment to tackle worry and overthinking called “rumination-focused cognitive behavioral therapy”
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A new study conducted by researchers at Florida International University, Miami, has found that communities in the United States with a high density of African Americans are disproportionately burdened with the adverse outcomes of coronavirus disease 2019 (COVID-19). The study, which assessed the three most populous counties in each state and territory, found that the
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A research group from Harvard Medical School reported two cryo-electron microscopy structures derived from a single preparation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein in their paper available on the preprint server bioRxiv*. Understanding the nuances of prefusion and postfusion conformations shed light on viral cell entry and may, in turn,
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Reviewed by Emily Henderson, B.Sc.May 15 2020 As stay-at-home orders are being lifted in some states and extended in others, uncertainty continues to surround the COVID-19 pandemic. Serious measures have been implemented the world over -; from cancellations of major events and large gatherings to closures of schools and non-essential businesses. You might be wondering
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Reviewed by Emily Henderson, B.Sc.May 15 2020 A team of anthropologists, physicians, tribal leaders and local government authorities developed and implemented a multi-phase COVID-19 prevention and containment plan among the Tsimane, an indigenous group of forager-horticulturists in the Bolivian Amazon. The collaborative effort is led by Hillard Kaplan, Ph.D., professor of health economics and anthropology
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Reviewed by Emily Henderson, B.Sc.May 14 2020 Daniel Preston, an assistant professor of mechanical engineering at Rice’s Brown School of Engineering, has received a National Science Foundation Rapid Response Research grant to study the effect of varying temperatures on the lifetime of the virus responsible for the COVID-19 pandemic. The project is titled “Thermal sterilization
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Reviewed by Emily Henderson, B.Sc.May 13 2020 Led by Lawson Health Research Institute, London Health Sciences Centre (LHSC), University Health Network (UHN) and General Dynamics Land Systems-Canada (GDLS-Canada), researchers have designed a non-invasive ventilation mask that could significantly reduce aerosolization – the production of airborne respiratory droplets that may contain viruses or bacteria – when
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Reviewed by Emily Henderson, B.Sc.May 12 2020 Children and young adult burn survivors are more troubled by staring, bullying, and uncomfortable questions than the actual physical discomfort and memories of their accidents, according to research that was selected to be presented at the American Burn Association’s Annual Meeting and published in the Journal of Burn
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Reviewed by Emily Henderson, B.Sc.May 11 2020 A new technique could provide vital information about a community’s immunity to infectious diseases including malaria and COVID-19. The diagnostic test analyses a blood sample to reveal immune markers that indicate whether – and when – a person was exposed to an infection. It was developed to track
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Reviewed by Emily Henderson, B.Sc.May 7 2020 The germline is the cell lineage of an organism that passes on its genetic material to its progeny. Genetic damage to the germline can cause developmental defects and even death of that same progeny. It is thought that biological mechanisms exist that ensure that aberrant germline cells are
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Reviewed by Emily Henderson, B.Sc.May 6 2020 Neuroscientists at MIT’s Picower Institute for Learning and Memory have found that a protein acts like a volume dial for the release of neurotransmitters, the chemicals that neurons release across connections called synapses to stimulate muscles or communicate with other neurons in brain circuits. The findings help explain
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Reviewed by Emily Henderson, B.Sc.May 4 2020 Artificial intelligence (AI) may be an aid to interpreting ECG results, helping healthcare staff to diagnose diseases that affect the heart. Researchers at Uppsala University and heart specialists in Brazil have developed an AI that automatically diagnoses atrial fibrillation and five other common ECG abnormalities just as well
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Reviewed by Emily Henderson, B.Sc.May 3 2020 Since the World Health Organization declared COVID-19 a Public Health Concern of Global Interest on January 30, more than one million have tested positive for the illness in the United States, and more than 62,000 have died. With no FDA-approved treatments available to date, the anti-malarial drug, hydroxychloroquine,
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Reviewed by Emily Henderson, B.Sc.May 2 2020 Researchers at EMBL’s European Bioinformatics Institute (EMBL-EBI), the University of Dundee and the Wellcome Sanger Institute analyzed over 2700 genomes from C. elegans worms in order to better understand the causes of mutations. Their findings, published today in Nature Communications, characterize how DNA mutations result from the combined
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May 1 2020 Through serendipity, researchers at the University of Pittsburgh Graduate School of Public Health considerably reduced the toxicity of a potential antibiotic against the most feared drug-resistant bacteria, while also improving its stability in fighting infections. Image Credits: royaltystockphoto.com / Shutterstock.com The new antibiotic — administered via the windpipe to target lung infections
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Reviewed by Emily Henderson, B.Sc.Apr 29 2020 Today, the Chan Zuckerberg Initiative (CZI) announced $14 million in funding to support 29 interdisciplinary teams and build a network of researchers that will explore emerging ideas regarding the role of inflammation in disease. While inflammation is a natural defense that helps our bodies maintain a healthy state,
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Reviewed by Emily Henderson, B.Sc.Apr 28 2020 With antimicrobial resistance (AMR) increasing around the world, new research led by the University of Bristol has shown a new drug formulation could possibly be used in antifungal treatments against Candida infections. Candida albicans, a well-known yeast usually seen in the mouth, skin, gut and vagina, is reported
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Reviewed by Emily Henderson, B.Sc.Apr 27 2020 Although today’s rheumatoid arthritis treatments can reduce symptoms, they often come with serious side effects. Results from a new mouse study suggest that a new light-activated drug delivery method helps confine treatments to the joints, which could reduce whole-body side effects. In the U.S., 1.3 million people are
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OU Medicine, the OU Health Sciences Center and the Oklahoma Medical Research Foundation collaborated to create a new test for COVID-19 using technology and reagents from Fluidigm Corporation, an innovative biotechnology tools provider. The test is intended for large-scale testing of patients across the OU Medicine healthcare system, with the capacity to test 180,000 samples
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