Allergies & Asthma

A first-in-class drug under development for severe asthma passed what its developers hope is the final test: achieving its primary endpoint in a phase III registration trial dubbed NAVIGATOR and now reported in a major journal. Tezepelumab, a monoclonal antibody targeting thymic stromal lymphopoietin (TSLP), cut the annualized rate of asthma exacerbations by more than
0 Comments
A novel gene therapy for severe combined immunodeficiency from adenosine deaminase deficiency (ADA-SCID) restored immune cell counts without death or need for enzyme replacement therapy, researchers reported. Survival without needing to re-initiate pegylated ADA enzyme replacement therapy, or have a rescue allogeneic hematopoietic stem cell transplantation (AHCT), was 95% to 97% at last follow-up at
0 Comments
Rather than site-wide food bans or allergen-restricted zones, allergy training, action plans, and available epinephrine to treat suspected anaphylaxis are recommended to address allergic reactions to food at child care centers and schools, according to new practice guidelines. Not only has research found little evidence that food bans work, such restrictions can pose monitoring and
0 Comments
Contents of baby’s first stool were a biomarker for early-life allergy risk in a study of 100 infants. Infants who developed IgE-mediated atopy by age 1 showed a significantly poorer environment in their meconium — the fecal matter accumulated prior to birth and typically expelled within a few days of delivery — for microbiotal development
0 Comments
As the world starts to emerge from the COVID-19 crisis, another global — and even more devastating — existential threat persists: climate change. Worldwide, climate-driven disasters including storms, droughts, fires, and floods displaced more than 10 million people since last September. Here in the western U.S., we face increasingly catastrophic wildfire seasons with powerful effects
0 Comments
A graded dosing protocol allowed two patients with hypersensitivity reactions to the first dose of Moderna’s COVID-19 vaccine to receive their second doses safely, researchers said. The patients — one with an immediate hypersensitivity reaction managed on site and one needing emergency department transport — got divided second doses, reported S. Shahzad Mustafa, MD, of
0 Comments
Asthma patients with confirmed COVID-19 were no more likely to require hospitalization or mechanical ventilation than patients without asthma, researchers found. Moreover, the asthma patients were less likely to die from COVID, reported Lacey Robinson, MD, of Massachusetts General Hospital in Boston, at the virtual annual meeting of the American Academy of Allergy, Asthma &
0 Comments
Inhaled budesonide (Pulmicort), a steroid generally used to treat asthma, dramatically reduced the need for hospitalization in COVID-19 patients within a week of symptom onset, a small randomized trial in the U.K. found. Among 139 patients with mild COVID-19 symptoms, 10 in the control group required either a COVID-19-related urgent care or emergency department (ED)
0 Comments
Barbecue can return to the menu for individuals with “alpha-gal” syndrome — severe allergic reactions to the alpha-galactose saccharide found in red meat — with FDA approval Monday of pigs engineered to lack an enzyme considered key to the condition. Developed by a company called Revivicor, the “GalSafe” pigs might also have therapeutic potential as
0 Comments