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Most clinical practice guidelines in the U.S. are created by medical specialty societies. While there is widespread awareness of the potential for intellectual and financial conflict of interest by individual panel members, there is little recognition of the potential for the processes used by guideline panels to create conflict of interest. This is particularly important
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Put a seemingly timid child with congenital heart disease (CHD) on a treadmill, attach electrodes to their chest and place a mask over their mouth and nose to measure gas exchange, and it’s amazing what you can learn about their cardiovascular and pulmonary health. That’s the premise behind Children’s of Alabama’s new Cardiometabolic Exercise Testing
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Andre Pearson, a heart failure patient who has been at Mayo Clinic since March, initially was too ill to leave the Rochester, Minn., hospital to go to his daughter’s wedding in California. He had resigned himself to watching it online. But a few days before the Saturday evening ceremony, with Mr. Pearson doing well, his
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Researchers have developed a method to estimate cardiorespiratory fitness levels that could be applied to data captured by wearable fitness trackers during activities of daily life. This could facilitate testing for those with low exercise tolerance and may reduce the need for medically supervised fitness testing. The study is published ahead of print in the
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A common variation in a human gene that affects the brain’s reward processing circuit increases vulnerability to the rewarding effects of the main psychoactive ingredient of cannabis in adolescent females, but not males, according to preclinical research by Weill Cornell Medicine investigators. As adolescence represents a highly sensitive period of brain development with the highest
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A new study investigating factors that contribute to psychological distress in adults has found that that risk of malnourishment is linked to psychological distress among Canadians aged 45 years and older. “These findings are consistent with other research which has found links between poor quality diet, and depression, bipolar disorder, and psychological distress,” says study
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A woman wears a protective mask as she rides a bicycle on February 11.2020 in Wuhan. Hubei province, China. Flights, trains and public transport including buses, subway and ferry services have been closed for the twentieth days. Getty Images This is a live blog. Please check back for updates. All times below are in Beijing
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The field of heart failure in pediatric populations has recently initiated more registries and clinical trials. This age group has special concerns and particularities regarding their clinical picture and management. Therefore, multiple disciplines have been involved in the management of heart failure in this age group. The book Heart Failure in Pediatric Patients will solve
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In salt-sensitive hypertension, immune cells gather in the kidneys and shoot out free radicals, heightening blood pressure and damaging this pair of vital organs, scientists report. These highly reactive chemicals, also called reactive oxygen species, or ROS, are a byproduct of our body’s use of oxygen that our immune system uses to kill invaders. But
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Higher maternal blood pressure in pregnancy is associated with chemical modifications to placental genes, according to a study by researchers from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), part of the National Institutes of Health (NIH). The changes involve DNA methylation, the binding of compounds known as methyl groups
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A woman sits outside wearing a protective mask on February 9, 2020 in Wuhan, China. Flights, trains and public transport including buses, subway and ferry services have been closed for eighteenth days. The number of those who have died from the Wuhan coronavirus, known as 2019-nCoV, in China has climbed to 813. Stringer | Getty
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Prenatal supplementation with high-dose vitamin D had no impact on asthma and persistent wheezing in 6-year-olds in follow-up of a study that did suggest protection at age 3 years. Previously reported data from the Vitamin D Antenatal Asthma Reduction Trial (VDAART) showed a reduction in recurrent wheezing in 3-year-olds associated with being born to mothers
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Feb 7 2020 The European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) has today issued new guidance to physicians on the diagnosis of coeliac disease in children recommending the no-biopsy approach at diagnosis for the majority of children suspected of having the disease. Currently, around half of children with suspected celiac disease undergo a
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A cancer tumor’s ability to mutate allows it to escape from chemotherapy and other attempts to kill it. So, encouraging mutations would not be a logical path for cancer researchers. Yet a Mayo Clinic team and their collaborators took that counterintuitive approach and discovered that while it created resistance to chemotherapy, it also made tumors
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Pedestrians wearing protective face masks walk though the Chinatown neighborhood of New York, U.S., on Tuesday, Feb. 4, 2020. Michael Nagle | Bloomberg | Getty Images This is a live blog. Please check back for updates. All times below are in Beijing time. 8:40 am: Chinese social media erupts with condolences and anger over whistleblower
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